Hyperimmune Egg Clinical Studies

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Administration to Arthritis Patients of a Dietary Supplement Containing Immume Egg: An Open-Label Pilot Study Greenblatt, H. C., Adalsteinsson, O., and L. Kagen 1998 Journal of Medicinal Food 1:171-178.
Pilot Study on the effect of Hyperimmune Egg Protein on Elevated Cholesterol Levels and Cardiovascular Risk Factors Karge, W.H, DeLuca, J.P., Marchitelli, L., J., Champagne, C., Tulley, R., Rood, J., Paulos, M. A., and H. R. Lieberman 1999 Journal of Medicinal Food 2:51-63.
Hyperimmune Eggs Capture Natural Immune Support Dean, K. L. 2000 Alternative & Complementary Therapies 6:118-124.
Inhibition of Diarrhea by Immune Egg: A Castor Oil Mouse Model Jacoby, H. I., Moore, G., and G. Wnorowski 2001 Journal of Nutraceuticals, Functional & Medical Foods 3:47-53.
Improvements in Quality of Life for HIV/AIDS Patients Using Hyperimmune Egg — The TASO Study Kizito, FB 2005 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment Abstract MoPe11.2C43
Hyperimmune Egg Protein Decreases Submaximal Heart Rate and Increases Peak Power  Scheett TM,  Martin TD , Carr BM, Koster CA, Celmer, PA, Whitener JA and M Webster  2007  Medicine  & Science in Sports Medicine & Exercise  39:S365.

Increased Muscular Strength and Enhanced Muscle Repair with Hyperimmune Egg Protein Supplementation Scheett TM,  Martin TD , Carr BM, Koster CA, Celmer, PA, Whitener JA and M Webster  2007 National Strength & Conditioning Association Poster Session p. 768.

Egg Yolk Antibodies for Passive Immunity Jennifer Kovacs-Nolan and Yoshinori Mine; Annual Review of Food Science and Technology 2012 3:163-82



Hyperimmune Egg Protein Supplementation Stimulates the GH→IGH-1 Axis..  Scheett, T.P., Boland, C.G., Rivera, L.E., Martin, T.D., Carr, B.M., and Webster, M.J.  2008  National Strength and Conditioning Association, Las Vegas, NV

Effect of the Hyperimmune Egg Supplement on Regulation of Insulin-Like Growth Factor-I. Rivera, L.E., C.G. Boland, and T.P. Scheett. 2008 Southeast American College of Sports Medicine, Birmingham, AL.

Effect of the Hyperimmune Egg Supplement on Anabolic Mediators of Muscle Repair. Boland, C.G., L.E. Rivera, and T.P. Scheett.  2008Southeast American College of Sports Medicine, Birmingham, AL.

Increased Muscular Strength and Enhanced Muscle Repair with Hyperimmune Egg Protein Supplementation.  Scheett, T.P., T.D. Martin, B.M. Carr, C.A. Koster, P.A. Celmer, J.A. Whitener, and M.J. Webster.. 2007 National Strength and Conditioning Association, Atlanta, GA
Hyperimmune Egg Protein Decreases Submaximal Heart Rate and Increase Peak Power.  Scheett, T.P., T.D. Martin, B.M. Carr, C.A. Koster, P.A. Celmer, J.A. Whitener, and M.J. Webster. 2007 American College of Sports Medicine, New Orleans, LA
Hyperimmune Egg: Its Ability to Maintain Weight and Lean Muscle Mass in Individuals with Cachexia Rhenni Ambekar, M. D. and Vinod Chungi, Ph. D.
Null Effect of Test Articles After Injection of Rats with Mycobacterium butyricum [Contract Research Organization]
Lack of Effect of Immune Egg in Preventing Rat Paw Edema after Injection with 5% Formalin or Carrageenan Alan Cowan, Ph. D.
The Effect of Egg Powder on Intradermal Carrageenan Injection of Female Beagles [working title] Jeff Hunchar, D.V.M..
Null Effect of Hyperimmune Egg in Preventing Dextran Sulfate Sodium-Induced Stimulation in Rodents Jacoby, H., Brodie, D. Wnorowski, G. and G. Moore
Effect of Immune Egg in Animals Injected with Type II collagen [working title] Trentham, D., Daley, M., Fitzpatrick-McElligott, S. and R. Dynesius-Trentham
The Effect of Immune Eggs on NZW Rabbits on High Cholesterol Diets Wilborn, W., Pierce, T., Hyde, B., Coleman, W., Weaver, J., Gaston, T., and S-C Xiang (unpublished)
Effect of Immune Egg on Serum Cholesterol in Rabbits on Atherogenic Diets Wilborn, W., Pierce, T., Hyde, B., Coleman, W., Weaver, J., Gaston, T. and S-C Xiang (unpublished)
The Dampening Effect of Hyperimmune Egg on Carrageenan-Induced Neutrophil Migration Wilborn, W., Pierce, T., Hyde, B., and Xiang, S-C

(Due to licensing issues we are unfortunately unable to directly link to the abstract or paper listed below. However, you may access abstracts on PubMed

Barnes, G. L., Hewson, P. H., McLellan, J. A., Doyle, L. W., Knoches, A. M. L., and Kitchen, W. H. 1982. A Randomized Trial of Oral Gamma globulin in Low-Birth-Weight Infants Infected with Rotavirus Lancet 1:1371-1373.

Borowitz S. M., and Saulsbury, F. T. 1991. Treatment of Chronic Cryptospoidial Infection with Orally Administered Human Serum Immune globulin. J. Pediatr 119:593-595.

Bogstedt, A. K., Johansen, K., Hatta, H. Kim, M., Casswall, T., Svensson, L., and Hammarström, L. 1996 Passive Immunity Against Diarrhoea Acta Paediatr 85:125-128.

Brunser, O., Espinoza, J., Figueroa, G., Araya, M., Spencer, E., Hilpert, H., Link-Amster, H., and Brüssow, H. 1992. Field Trial of an Infant Formula Containing Anti-Rotavirus and Anti-Escherichia coli Milk Antibodies from Hyperimmunized Cows. J Pediatr Gastroenterol Nutr 15:63-72.

Casswall T. H., Hammarstrom, L., Veress, B., Nord, C. E., Bogstedt, A., Brockstedt, U., and Dahlstrom, K. A. 1996. Oral IgA-IgG Treatment of Chronic Non-Specific Diarrhoea in Infants and Children. Acta Paediatr Scand 85:1126-1128.

Dohler, J. R., and Nebermann, L. 2002 Bovine Colostrum in Oral Treatment of Enterogenic Endotoxaemia in Rats Critical Care 6:536-539.

Ebina, T., Sato, A. Umezu, K, Ishida, N., Ohyama, S. Oizumi, A., Aikawa, K., Katagiri, S., Katsushima, N., Imai, A., Kitaoka, S., Suzuki, H., and Konno, T. 1985. Prevention of Rotavirus Infection by Oral Administration of Cow Colostrum Containing Anti-Human Rotavirus Antibody Med Micro Immun174:177-185.

Eibl, M. M., Wolf, H. M., Fürnkranz, H., and Rosenkranz, A. 1988. Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG Feeding. N Eng J Med. 319:1-7.

Fan M, Jiang Q., and Bian Z. 2003 [The Study on Specific Anti-Streptococcus mutans IgY Against Dental Caries in Rats] Hua Xi Kou Qiang Yi Xue Za Zhi 21:339-41.  

Foster J., and Cole M. 2004 Oral Immunoglobulin for Preventing Necrotizing Enterocolitis in Preterm and Low Birth-Weight Neonates. The Cochrane Database of Systematic Reviews 2004, Issue 1. [Null study]

Guarino, A., Guandalini, S., Albano, F., Mascia, A., De Rits, G., and Rubino, A. 1991 Enteral immunoglobulins for Treatment of Protracted Rotaviral Diarrhea. Pediatr Infect Dis J 10:612-614.

Guarino, A., Canai, R. B., Russo, S., Albano, F., Canani M. B., Ruggeri, F. M., Donelli, Gl., and Rubino, A. 1994. Oral Immunoglobulins for Treatment of Acute Rotaviral Gastroenteritis Pediatr 93:12-16.

Hilpert, H., Brussow, H. Mietens, C., Sidoti, J., Lerner, L., and Werchau, H. 1987 Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants. J Infect Dis 156:158-166.

Hiraga, C., Kodama, Y., Sugiyama, T., and Ichikawa, Y. 1990. Prevention of Human Rotavirus Infection with Chicken Egg Yolk Immunoglobulins Containing Rotavirus Antibody in Cat J Jpn Assoc of Infect Dis 64:118-123.

Horie K, Horie N, Abdou AM, Yang JO, Yun SS, Chun HN, Park CK, Kim M,, and Hatta H. 2004 Suppressive Effect of Functional Drinking Yogurt Containing Specific Egg Yolk Immunoglobulin on Helicobacter pylori in Humans. J Dairy Sci 87:4073-9.  

Kollberg H, Carlander D, Olesen H, Wejaker PE, Johannesson M., and Larsson A. 2003 Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonasaeruginosa infections in patients with cystic fibrosis: a phase I feasibility study. Pediatr Pulmonol 35:433-40.  

Larsson A., and Carlander D. 2003 Oral Immunotherapy with Yolk Antibodies to Prevent Infections in Humans and Animals. Ups J Med Sci 108:129-40.

Lo, C.W. and Kleinman, R. E. 1996. Infant Formula, Past and Future: Opportunities for Improvement. Am J Clin Nutr 63:646S-650S.

Losonsky, G. A., Johnson, J. P., Winkelstein, J. A., and Yolken, R. H. 1985. Oral Administration of Human Serum Immunoglobulin in Immunodeficient Patients with Viral Gastroenteritis J Clin Invest 76:2362-2367.

Melamed I., Griffiths, A. M., and Roifman, C. M. 1991. Benefit of Oral Immune Globulin Therapy in Patients with Immunodeficiency and Chronic Diarrhea. Journal Pediatrics 119:486-489.

Mietens, C. and Keinhorst, H. 1979. Treatment of Infantile E. coli Gastroenteritis with Specific Bovine anti-E. coli Milk Immunoglobulins Eur J Pediatr132:239-252.

Mine Y, and Kovacs-Nolan J. 2002 Chicken egg yolk antibodies as therapeutics in enteric infectious disease: a review J Med Food 5:159-69.  

Mohan P., and Haque K. 2005 Oral Immunoglobulin for the Prevention of Rotavirus Infection in Low Birth Weight Infants The Cochrane Library Issue 2. 

Petersen, W. E., and Campbell, B. 1955. Use of Protective Principles in Milk and Colostrum in Prevention of Disease in Man and Animals Lancet 75:494-496.

Tacket, C.O., Losonsky, G., Link, H. Hoang, Y., Guesry, P., Hilpert, H. and Levine, M.M. 1988. Protection by Milk Immunogloubulin Concentrate Against Oral Challenge with Enterotoxigenic Escherichia coli. N Eng Jof Med 318:1240-1243.

Tacket, C.O., Binion, S. B., Bostwick, E., Losonsky, G., Roy, M. J., and Edelman R. 1992. Efficacy of Bovine Milk Immunoglobulin Concentrate in Preventing Illness after Shigella flexneri Challenge. Am J Trop Med Hygi 47:276-283.

Tollemar,J., Gross N., Dolgiras N., Jarstrand C., Ringdén, O., and Hammarström, L. 1999 Fungal Prophylaxis by Reduction of Fungal Colonization by Oral Administration of Bovine Anti-Candida Antibodies in Bone Marrow Transplant Recipients Bone Marrow Transplant 23:283-290.

Tsunemitsu, H., Shimizu, M., Hirai, T., Yonemichi, H., Kudo, T., Mori, K., and Onoe S. 1989 Protection against Bovine Rotaviruses in Newborn Calves by Continuous Feeding of Immune Colostrum Jpn J Vet Sci 51:300-308.

Tzipori, S., Roberton, D., and Chapman, C. 1986. Remission of Diarrhea Due to Cryptosporidiosis in an Immunodeficient Child Treated with Hyperimmune Bovine Colostrum Br Med J 293:1276-1277.

Ungar, B. L. P., Ward, D. J., Fayer, R., and Quinn C. A. 1990 Cessation of Cryptosporidium-Associated Diarrhea in an Acquired Immunodeficiency Syndrome Patient After Treatment with Hyperimmune Bovine Colostrum Gastroenterology 98:486-489.

Wang WH, Wang WJ, Zhang BX. 2003 [Effect of IgY solution on dental plaque] Zhonghua Kou Qiang Yi Xue Za Zhi 38:417-9.  

Xie MQ, Meng YX, Li ZH, Li YQ, Zhang KX, Zhao XM, Xiong GJ, Chen YM. 2004 [Effect of Specific Immunoglobulin Y in the Treatment of Acute and Chronic Pharyngitis] Zhonghua Er Bi Yan Hou Ke Za Zhi 39:112-5.

Yolken, R., Losonsky, G. A., Vonderfecht, S., Leister, F. and Wee, S-B. 1985. Antibody to Human Rotavirus in Cow's Milk N Eng J Med 312:605-610.

Yolken, R. H., Leister, F., Wee, S-B., Miskuff, R., and Vonderfecht, S. 1988. Antibodies to Rotaviruses in Chickens' Eggs: A Potential Source of Antiviral Immunoglobulins Suitable for Human Consumption Pediatr 81:291-295.

Zhou Z, Zhou R, Tang Z. 2003 [Effects of Topical Application of Immunoglobulin Yolk on Mutans Streptococci in Dental Plaque] Hua Xi Kou Qiang Yi Xue Za Zhi. 21:295-7.